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Dissection of the Adenoviral VA RNA(I) Central Domain Structure Reveals Minimum Requirements for RNA-mediated Inhibition of PKR

Virus-associated RNA I (VA RNA(I)) is a short (∼160-nucleotide) non-coding RNA transcript employed by adenoviruses to subvert the innate immune system protein double-stranded RNA-activated protein kinase (PKR). The central domain of VA RNA(I) is proposed to contain a complex tertiary structure that...

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Detalhes bibliográficos
Main Authors: Wilson, Jo L., Vachon, Virginia K., Sunita, S., Schwartz, Samantha L., Conn, Graeme L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132820/
https://ncbi.nlm.nih.gov/pubmed/24970889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550046
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