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Role of the interdomain linker in PKR activation
PKR is a key component of the interferon-induced antiviral pathway in higher eukaryotes. Upon recognition of viral dsRNA, PKR is activated via dimerization and autophosphorylation. PKR contains two N-terminal dsRNA binding domains (dsRBD) and a C-terminal kinase domain. The dsRBDs and the kinase are...
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| 發表在: | Biochemistry |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718896/ https://ncbi.nlm.nih.gov/pubmed/26678943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01171 |
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