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Domain Stabilities in PKR: Evidence for Weak Interdomain Interactions
PKR (protein kinase R) is induced by interferon and is a key component of the innate immunity antiviral pathway. Upon binding dsRNA, PKR undergoes autophosphorylation reactions that activate the kinase leading it to phosphorylate eIF2α, thus inhibiting protein synthesis in virally-infected cells. PK...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2729556/ https://ncbi.nlm.nih.gov/pubmed/18393532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702211j |
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