Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein

Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Jafari, Gholamali, Wasko, Brian M., Tonge, Ashley, Schurman, Nathan, Dong, Cindy, Li, Zhongyu, Peters, Rebecca, Kayser, Ernst-Bernhard, Pitt, Jason N., Morgan, Phil G., Sedensky, Margaret M., Crofts, Antony R., Kaeberlein, Matt
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653183/
https://ncbi.nlm.nih.gov/pubmed/26504246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509416112
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