Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein

Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Jafari, Gholamali, Wasko, Brian M., Tonge, Ashley, Schurman, Nathan, Dong, Cindy, Li, Zhongyu, Peters, Rebecca, Kayser, Ernst-Bernhard, Pitt, Jason N., Morgan, Phil G., Sedensky, Margaret M., Crofts, Antony R., Kaeberlein, Matt
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653183/
https://ncbi.nlm.nih.gov/pubmed/26504246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509416112
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