Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein

Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jafari, Gholamali, Wasko, Brian M., Tonge, Ashley, Schurman, Nathan, Dong, Cindy, Li, Zhongyu, Peters, Rebecca, Kayser, Ernst-Bernhard, Pitt, Jason N., Morgan, Phil G., Sedensky, Margaret M., Crofts, Antony R., Kaeberlein, Matt
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653183/
https://ncbi.nlm.nih.gov/pubmed/26504246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509416112
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