Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein

Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Jafari, Gholamali, Wasko, Brian M., Tonge, Ashley, Schurman, Nathan, Dong, Cindy, Li, Zhongyu, Peters, Rebecca, Kayser, Ernst-Bernhard, Pitt, Jason N., Morgan, Phil G., Sedensky, Margaret M., Crofts, Antony R., Kaeberlein, Matt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653183/
https://ncbi.nlm.nih.gov/pubmed/26504246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509416112
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