Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

[Image: see text] (E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate reductase (IspH) is a [Fe(4)S(4)] cluster-containing enzyme involved in isoprenoid biosynthesis in many bacteria as well as in malaria parasites and is an important drug target. Several inhibitors including amino and thiol substrate an...

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Bibliografiske detaljer
Main Authors: Span, Ingrid, Wang, Ke, Eisenreich, Wolfgang, Bacher, Adelbert, Zhang, Yong, Oldfield, Eric, Groll, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063180/
https://ncbi.nlm.nih.gov/pubmed/24813236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501127j
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