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Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation

The [4Fe-4S] protein IspH in the methylerythritol phosphate isoprenoid biosynthesis pathway is an important anti-infective drug target, but its mechanism of action is still the subject of debate. Here, by using electron paramagnetic resonance (EPR) spectroscopy and (2)H, (17)O, and (57)Fe isotopic l...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Weixue, Wang, Ke, Span, Ingrid, Jauch, Johann, Bacher, Adelbert, Groll, Michael, Oldfield, Eric
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394908/
https://ncbi.nlm.nih.gov/pubmed/22687151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303445z
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