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Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation
The [4Fe-4S] protein IspH in the methylerythritol phosphate isoprenoid biosynthesis pathway is an important anti-infective drug target, but its mechanism of action is still the subject of debate. Here, by using electron paramagnetic resonance (EPR) spectroscopy and (2)H, (17)O, and (57)Fe isotopic l...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394908/ https://ncbi.nlm.nih.gov/pubmed/22687151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303445z |
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