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Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

The mutation of T790M in EGFR is a major mechanism of resistance to treatment with EGFR-TKIs. Only qualitative detection (presence or absence) of T790M has been described to date, however. Digital PCR (dPCR) analysis has recently been applied to the quantitative detection of target molecules in canc...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Iwama, Eiji, Takayama, Koichi, Harada, Taishi, Okamoto, Isamu, Ookubo, Fumihiko, Kishimoto, Junji, Baba, Eishi, Oda, Yoshinao, Nakanishi, Yoichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653018/
https://ncbi.nlm.nih.gov/pubmed/26015401
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