Acquisition of the T790M resistance mutation during afatinib treatment in EGFR tyrosine kinase inhibitor–naïve patients with non–small cell lung cancer harboring EGFR mutations

The T790M secondary mutation of the epidermal growth factor receptor (EGFR) gene accounts for 50% to 60% of cases of resistance to the first-generation EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib. The prevalence of T790M in EGFR mutation–positive patients who acquire resistance to...

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Udgivet i:Oncotarget
Main Authors: Tanaka, Kentaro, Nosaki, Kaname, Otsubo, Kohei, Azuma, Koichi, Sakata, Shinya, Ouchi, Hiroshi, Morinaga, Ryotaro, Wataya, Hiroshi, Fujii, Akiko, Nakagaki, Noriaki, Tsuruta, Nobuko, Takeshita, Masafumi, Iwama, Eiji, Harada, Taishi, Nakanishi, Yoichi, Okamoto, Isamu
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620242/
https://ncbi.nlm.nih.gov/pubmed/28978102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19243
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