Clinical utility of liquid biopsy for EGFR driver, T790M mutation and EGFR amplification in plasma in patients with acquired resistance to afatinib

BACKGROUND: Cell-free DNA (cfDNA) genotyping in plasma using the cobas EGFR Mutation Test v2 (cobas) is the first liquid biopsy as a companion diagnosis to identify the EGFR T790M mutation (T790M) after the failure of treatment of EGFR-tyrosine kinase inhibitors (TKIs) (1st generation, gefitinib [G]...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Oya, Yuko, Yoshida, Tatsuya, Asada, Kazuhiro, Oguri, Tetsuya, Inui, Naoki, Morikawa, Sayako, Ito, Kentaro, Kimura, Tomoki, Kunii, Eiji, Matsui, Takashi, Kubo, Akihito, Kato, Tatsuo, Abe, Takashi, Tsuda, Takeshi, Hida, Toyoaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802126/
https://ncbi.nlm.nih.gov/pubmed/33435905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07777-2
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