RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth

The character of EGFR signals can influence cell fate but mechanistic insights into intestinal EGFR-Ras signalling are limited. Here we show that two distinct Ras nucleotide exchange factors, RasGRP1 and SOS1, lie downstream of EGFR but act in functional opposition. RasGRP1 is expressed in intestina...

Full description

Saved in:
Bibliographic Details
Published in:Nat Cell Biol
Main Authors: Depeille, Philippe, Henricks, Linda M., van de Ven, Robert A. H., Lemmens, Ed, Wang, Chih-Yang, Matli, Mary, Werb, Zena, Haigis, Kevin M., Donner, David, Warren, Robert, Roose, Jeroen P.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652934/
https://ncbi.nlm.nih.gov/pubmed/26005835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3175
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items