Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL, but the underlying mechanisms are unclear. Here, we identified the guanine nucleotide exchange factor RasGRP1 (Rasgrp1 in mice) as a Ras activator that contributes to leukem...

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Detalhes bibliográficos
Main Authors: Hartzell, Catherine, Ksionda, Olga, Lemmens, Ed, Coakley, Kristen, Yang, Ming, Dail, Monique, Harvey, Richard C., Govern, Christopher, Bakker, Jeroen, Lenstra, Tineke L., Ammon, Kristin, Boeter, Anne, Winter, Stuart S., Loh, Mignon, Shannon, Kevin, Chakraborty, Arup K., Wabl, Matthias, Roose, Jeroen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737252/
https://ncbi.nlm.nih.gov/pubmed/23532335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003848
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