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Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis
Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL, but the underlying mechanisms are unclear. Here, we identified the guanine nucleotide exchange factor RasGRP1 (Rasgrp1 in mice) as a Ras activator that contributes to leukem...
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| Glavni autori: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737252/ https://ncbi.nlm.nih.gov/pubmed/23532335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003848 |
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