Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases

Translesion DNA synthesis (TLS) by the Y-family DNA polymerases Polη, Polι and Polκ, mediated via interaction with proliferating cell nuclear antigen (PCNA), is a crucial pathway that protects human cells against DNA damage. We report that Polη has three PCNA-interacting protein (PIP) boxes (PIP1, 2...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Masuda, Yuji, Kanao, Rie, Kaji, Kentaro, Ohmori, Haruo, Hanaoka, Fumio, Masutani, Chikahide
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652755/
https://ncbi.nlm.nih.gov/pubmed/26170230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv712
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