MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells

Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple cellular processes including proliferation, differentiation, cell migration and cell survival. Deregulation of the EGFR signaling has been found to...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Presutti, Dario, Santini, Simonetta, Cardinali, Beatrice, Papoff, Giuliana, Lalli, Cristiana, Samperna, Simone, Fustaino, Valentina, Giannini, Giuseppe, Ruberti, Giovina
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651538/
https://ncbi.nlm.nih.gov/pubmed/26580964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143333
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