Crizotinib with or without an EGFR-TKI in treating EGFR-mutant NSCLC patients with acquired MET amplification after failure of EGFR-TKI therapy: a multicenter retrospective study

BACKGROUND: MET amplification is associated with acquired resistance to first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in treating non-small-cell lung cancer (NSCLC); however, the therapeutic strategy in these patients is undefined. Herein we report the cl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Transl Med
Hauptverfasser: Wang, Wenxian, Wang, Hong, Lu, Peihua, Yu, Zongyang, Xu, Chunwei, Zhuang, Wu, Song, Zhengbo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385446/
https://ncbi.nlm.nih.gov/pubmed/30791921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1803-9
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