Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons

Many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals and axons precedes the demise of dopaminergic neurons in the substantia nigra, which finally results in the clinical symptoms of Parkinson disease (PD). The mechanisms underlying this early axonal...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Koch, J C, Bitow, F, Haack, J, d'Hedouville, Z, Zhang, J-N, Tönges, L, Michel, U, Oliveira, L M A, Jovin, T M, Liman, J, Tatenhorst, L, Bähr, M, Lingor, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650722/
https://ncbi.nlm.nih.gov/pubmed/26158517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.169
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