Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease

The dopaminergic (DAergic) nigrostriatal tract has an intrinsic regenerative capacity which can be impaired in Parkinson's disease (PD). Alpha-synuclein (aSyn) is a major pathogenic component in PD but its impact on DAergic axonal regeneration is largely unknown. In this study, we expressed pat...

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Autors principals: Tönges, Lars, Szegö, Éva M., Hause, Patrizia, Saal, Kim-Ann, Tatenhorst, Lars, Koch, Jan Christoph, d`Hedouville, Zara, Dambeck, Vivian, Kügler, Sebastian, Dohm, Christoph P., Bähr, Mathias, Lingor, Paul
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159996/
https://ncbi.nlm.nih.gov/pubmed/25309425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00239
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