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Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease

Axonal degeneration is one of the earliest features of Parkinson’s disease pathology, which is followed by neuronal death in the substantia nigra and other parts of the brain. Inhibition of axonal degeneration combined with cellular neuroprotection therefore seem key to targeting an early stage in P...

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Detalhes bibliográficos
Main Authors: Tönges, Lars, Frank, Tobias, Tatenhorst, Lars, Saal, Kim A., Koch, Jan C., Szegő, Éva M., Bähr, Mathias, Weishaupt, Jochen H., Lingor, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501973/
https://ncbi.nlm.nih.gov/pubmed/23087045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aws254
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