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Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells
The Rho/ROCK pathway is a promising therapeutic target in neurodegenerative and neurotraumatic diseases. Pharmacological inhibition of various pathway members has been shown to promote neuronal regeneration and survival. However, because pharmacological inhibitors are inherently limited in their spe...
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| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155783/ https://ncbi.nlm.nih.gov/pubmed/25249936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00273 |
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