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Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a first-line antitubercular drug for which the mode of action remains unresolved. Mycobacterium tuberculosis lacks measurable susceptibility to PZA under standard laboratory growth conditions. However, susceptibility to this drug can be induced by cultivation of the bacilli in...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Peterson, Nicholas D., Rosen, Brandon C., Dillon, Nicholas A., Baughn, Anthony D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649215/
https://ncbi.nlm.nih.gov/pubmed/26369957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00967-15
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