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Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a first-line antitubercular drug for which the mode of action remains unresolved. Mycobacterium tuberculosis lacks measurable susceptibility to PZA under standard laboratory growth conditions. However, susceptibility to this drug can be induced by cultivation of the bacilli in...

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發表在:Antimicrob Agents Chemother
Main Authors: Peterson, Nicholas D., Rosen, Brandon C., Dillon, Nicholas A., Baughn, Anthony D.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649215/
https://ncbi.nlm.nih.gov/pubmed/26369957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00967-15
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