Inhibition of Isolated Mycobacterium tuberculosis Fatty Acid Synthase I by Pyrazinamide Analogs

An analog of pyrazinamide (PZA), 5-chloropyrazinamide (5-Cl-PZA), has previously been shown to inhibit mycobacterial fatty acid synthase I (FASI). FASI has been purified from a recombinant strain of M. smegmatis (M. smegmatis Δfas1 attB::M. tuberculosis fas1). Following purification, FASI activity a...

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Библиографические подробности
Главные авторы: Ngo, Silvana C., Zimhony, Oren, Chung, Woo Jin, Sayahi, Halimah, Jacobs, William R., Welch, John T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2007
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913273/
https://ncbi.nlm.nih.gov/pubmed/17485499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01458-06
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