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Pantothenate and Pantetheine Antagonize the Antitubercular Activity of Pyrazinamide
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA)....
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| Publicado no: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4249577/ https://ncbi.nlm.nih.gov/pubmed/25246400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04028-14 |
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