Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

Pyrazinamide (PZA) is an important antituberculosis drug. Unlike most antibacterial agents, PZA, despite its remarkable in vivo activity, has no activity against Mycobacterium tuberculosis in vitro except at an acidic pH. M. tuberculosis is uniquely susceptible to PZA, but other mycobacteria as well...

ver descrição completa

Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Zhang, Ying, Scorpio, Angelo, Nikaido, Hiroshi, Sun, Zhonghe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Physiology and Metabolism
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC93615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10094680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.181.7.2044-2049.1999
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!