Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

Tools for rapid and efficient transgenesis in “safe harbor” loci in an isogenic context remain important to exploit the possibilities of human pluripotent stem cells (hPSCs). We created hPSC master cell lines suitable for FLPe recombinase-mediated cassette exchange (RMCE) in the AAVS1 locus that all...

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出版年:Stem Cell Reports
主要な著者: Ordovás, Laura, Boon, Ruben, Pistoni, Mariaelena, Chen, Yemiao, Wolfs, Esther, Guo, Wenting, Sambathkumar, Rangarajan, Bobis-Wozowicz, Sylwia, Helsen, Nicky, Vanhove, Jolien, Berckmans, Pieter, Cai, Qing, Vanuytsel, Kim, Eggermont, Kristel, Vanslembrouck, Veerle, Schmidt, Béla Z., Raitano, Susanna, Van Den Bosch, Ludo, Nahmias, Yaakov, Cathomen, Toni, Struys, Tom, Verfaillie, Catherine M.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2015
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オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649136/
https://ncbi.nlm.nih.gov/pubmed/26455413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.09.004
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