Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer

Background Lapatinib has proven efficacy as monotherapy and in combination with capecitabine in patients with metastatic breast cancer (MBC) overexpressing HER2 and/or EGFR. Gemcitabine also has anti-tumor activity in MBC and a favourable toxicity profile. In this phase I study lapatinib and gemcita...

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Dettagli Bibliografici
Pubblicato in:Invest New Drugs
Autori principali: van der Noll, R., Smit, W. M., Wymenga, A. N. M., Boss, D. S., Grob, M., Huitema, A. D. R., Rosing, H., Tibben, M. M., Keessen, M., Rehorst, H., Beijnen, J. H., Schellens, J. H. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2015
Soggetti:
Phase I Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648969/
https://ncbi.nlm.nih.gov/pubmed/26362459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-015-0281-z
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