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Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents
Background The phase I program of anticancer agents usually consists of multiple dose escalation studies to select a safe dose for various administration schedules. We hypothesized that pharmacokinetic and pharmacodynamic (PK–PD) modeling of an initial phase I study (stage 1) can be used for selecti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810279/ https://ncbi.nlm.nih.gov/pubmed/19198760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-008-9216-2 |
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