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Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies

In cancer chemotherapy neutropenia is a common dose-limiting toxicity. An ability to predict the neutropenic effects of cytotoxic agents based on proposed trial designs and models conditioned on previous studies would be valuable. The aim of this study was to evaluate the ability of a semi-mechanist...

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Sonraí Bibleagrafaíochta
Main Authors: Soto, Elena, Keizer, Ron J., Trocóniz, Iñaki F., Huitema, Alwin D. R., Beijnen, Jos H., Schellens, Jan H. M., Wanders, Jantien, Cendrós, Josep María, Obach, Rosendo, Peraire, Concepción, Friberg, Lena E., Karlsson, Mats O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer US 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160557/
https://ncbi.nlm.nih.gov/pubmed/20449627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9437-z
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