Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed >50 % inhibition at 5 μm. Screening of these hits in a T. b. brucei proliferation assay highlighted three compounds with a 1H-imida...

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Published in:ChemMedChem
Main Authors: Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648050/
https://ncbi.nlm.nih.gov/pubmed/26381210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500300
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