PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients

BACKGROUND: PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of the PI3K/AKT pathway. Here, we developed a novel CTC-based assay to determine PTEN status and examined the correlation between PTEN status in CTCs and matched t...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Punnoose, Elizabeth A, Ferraldeschi, Roberta, Szafer-Glusman, Edith, Tucker, Eric K, Mohan, Sankar, Flohr, Penelope, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rodrigues, Daniel Nava, Omlin, Aurelius, Pezaro, Carmel, Zhu, Jin, Amler, Lukas, Patel, Premal, Yan, Yibing, Bales, Natalee, Werner, Shannon L, Louw, Jessica, Pandita, Ajay, Marrinucci, Dena, Attard, Gerhardt, de Bono, Johann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647881/
https://ncbi.nlm.nih.gov/pubmed/26379078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.332
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