PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients

BACKGROUND: PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of the PI3K/AKT pathway. Here, we developed a novel CTC-based assay to determine PTEN status and examined the correlation between PTEN status in CTCs and matched t...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Punnoose, Elizabeth A, Ferraldeschi, Roberta, Szafer-Glusman, Edith, Tucker, Eric K, Mohan, Sankar, Flohr, Penelope, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rodrigues, Daniel Nava, Omlin, Aurelius, Pezaro, Carmel, Zhu, Jin, Amler, Lukas, Patel, Premal, Yan, Yibing, Bales, Natalee, Werner, Shannon L, Louw, Jessica, Pandita, Ajay, Marrinucci, Dena, Attard, Gerhardt, de Bono, Johann
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Molecular Diagnostics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647881/
https://ncbi.nlm.nih.gov/pubmed/26379078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.332
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki