PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

BACKGROUND: Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) occurs frequently in prostate cancers. Preclinical evidence suggests that activation of PI3K/AKT signaling through loss of PTEN can result in resistance to hormonal treatment in prostate cancer. OBJECTIVE: To explore the...

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Bibliografiset tiedot
Julkaisussa:Eur Urol
Päätekijät: Ferraldeschi, Roberta, Nava Rodrigues, Daniel, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rescigno, Pasquale, Ravi, Praful, Pezaro, Carmel, Omlin, Aurelius, Lorente, David, Zafeiriou, Zafeiris, Mateo, Joaquin, Altavilla, Amelia, Sideris, Spyridon, Bianchini, Diletta, Grist, Emily, Thway, Khin, Perez Lopez, Raquel, Tunariu, Nina, Parker, Chris, Dearnaley, David, Reid, Alison, Attard, Gerhardt, de Bono, Johann
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Science 2015
Aiheet:
Prostate Cancer
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410287/
https://ncbi.nlm.nih.gov/pubmed/25454616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2014.10.027
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