PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

BACKGROUND: Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) occurs frequently in prostate cancers. Preclinical evidence suggests that activation of PI3K/AKT signaling through loss of PTEN can result in resistance to hormonal treatment in prostate cancer. OBJECTIVE: To explore the...

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Bibliographic Details
Published in:Eur Urol
Main Authors: Ferraldeschi, Roberta, Nava Rodrigues, Daniel, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rescigno, Pasquale, Ravi, Praful, Pezaro, Carmel, Omlin, Aurelius, Lorente, David, Zafeiriou, Zafeiris, Mateo, Joaquin, Altavilla, Amelia, Sideris, Spyridon, Bianchini, Diletta, Grist, Emily, Thway, Khin, Perez Lopez, Raquel, Tunariu, Nina, Parker, Chris, Dearnaley, David, Reid, Alison, Attard, Gerhardt, de Bono, Johann
Format: Artigo
Language:Inglês
Published: Elsevier Science 2015
Subjects:
Prostate Cancer
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410287/
https://ncbi.nlm.nih.gov/pubmed/25454616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2014.10.027
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