PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

BACKGROUND: Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) occurs frequently in prostate cancers. Preclinical evidence suggests that activation of PI3K/AKT signaling through loss of PTEN can result in resistance to hormonal treatment in prostate cancer. OBJECTIVE: To explore the...

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Bibliografische gegevens
Gepubliceerd in:Eur Urol
Hoofdauteurs: Ferraldeschi, Roberta, Nava Rodrigues, Daniel, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, Rescigno, Pasquale, Ravi, Praful, Pezaro, Carmel, Omlin, Aurelius, Lorente, David, Zafeiriou, Zafeiris, Mateo, Joaquin, Altavilla, Amelia, Sideris, Spyridon, Bianchini, Diletta, Grist, Emily, Thway, Khin, Perez Lopez, Raquel, Tunariu, Nina, Parker, Chris, Dearnaley, David, Reid, Alison, Attard, Gerhardt, de Bono, Johann
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Science 2015
Onderwerpen:
Prostate Cancer
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410287/
https://ncbi.nlm.nih.gov/pubmed/25454616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2014.10.027
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