Emerging role of PTEN loss in evasion of the immune response to tumours

Mutations in PTEN activate the phosphoinositide 3-kinase (PI3K) signalling network, leading to many of the characteristic phenotypic changes of cancer. However, the primary effects of this gene on oncogenesis through control of the PI3K–AKT–mammalian target of rapamycin (mTOR) pathway might not be t...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Vidotto, Thiago, Melo, Camila Morais, Castelli, Erick, Koti, Madhuri, dos Reis, Rodolfo Borges, Squire, Jeremy A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283470/
https://ncbi.nlm.nih.gov/pubmed/32327707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0834-6
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