Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

PURPOSE: The paradigm shift in cancer treatment from cytotoxic drugs to tumor targeted therapies poses new challenges, including optimization of dose and schedule based on a biologically effective dose, rather than the historical maximum tolerated dose. Optimal dosing is currently determined using c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Spector, Neil L., Robertson, Faith C., Bacus, Sarah, Blackwell, Kimberly, Smith, Deborah A., Glenn, Kelli, Cartee, Leanne, Harris, Jennifer, Kimbrough, Carie L., Gittelman, Mark, Avisar, Eli, Beitsch, Peter, Koch, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646457/
https://ncbi.nlm.nih.gov/pubmed/26571496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142845
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