Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

PURPOSE: The paradigm shift in cancer treatment from cytotoxic drugs to tumor targeted therapies poses new challenges, including optimization of dose and schedule based on a biologically effective dose, rather than the historical maximum tolerated dose. Optimal dosing is currently determined using c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Spector, Neil L., Robertson, Faith C., Bacus, Sarah, Blackwell, Kimberly, Smith, Deborah A., Glenn, Kelli, Cartee, Leanne, Harris, Jennifer, Kimbrough, Carie L., Gittelman, Mark, Avisar, Eli, Beitsch, Peter, Koch, Kevin M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646457/
https://ncbi.nlm.nih.gov/pubmed/26571496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142845
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