Lapatinib in Combination with Radiation Diminishes Tumor Regrowth in HER2+ and Basal-Like/EGFR+ Breast Tumor Xenografts

PURPOSE: To determine whether lapatinib, a dual epidermal growth factor receptor (EGFR)/HER2 kinase inhibitor, can radiosensitize EGFR+ or HER2+ breast cancer xenografts. METHODS AND MATERIALS: Mice bearing xenografts of basal-like/EGFR+ SUM149 and HER2+ SUM225 breast cancer cells were treated with...

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Hauptverfasser: Sambade, Maria J., Kimple, Randall J., Camp, J. Terese, Peters, Eldon, Livasy, Chad A., Sartor, Carolyn I., Shields, Janiel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976524/
https://ncbi.nlm.nih.gov/pubmed/20457354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.12.063
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