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Radiosensitization of EGFR/HER2 positive pancreatic cancer is mediated by inhibition of Akt independent of Ras mutational status
PURPOSE: Epidermal growth factor receptor family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provid...
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Huvudupphovsmän: | , , , , , , , |
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Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
2010
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818631/ https://ncbi.nlm.nih.gov/pubmed/20103665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1324 |
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