Radiosensitization of EGFR/HER2 positive pancreatic cancer is mediated by inhibition of Akt independent of Ras mutational status

PURPOSE: Epidermal growth factor receptor family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provid...

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Bibliografski detalji
Glavni autori: Kimple, Randall J., Vaseva, Angelina V., Cox, Adrienne D., Baerman, Kathryn M., Calvo, Benjamin F., Tepper, Joel E., Shields, Janiel M., Sartor, Carolyn I.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818631/
https://ncbi.nlm.nih.gov/pubmed/20103665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1324
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