Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways

Lapatinib is a clinically potent kinase inhibitor for breast cancer patients because of its outstanding selectivity for epidermal growth factor receptor (EGFR) and EGFR2 (also known as HER2). However, there is only limited information about the in vivo effects of lapatinib on EGFR/HER2 and downstrea...

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Detalhes bibliográficos
Main Authors: Imami, Koshi, Sugiyama, Naoyuki, Imamura, Haruna, Wakabayashi, Masaki, Tomita, Masaru, Taniguchi, Masatoshi, Ueno, Takayuki, Toi, Masakazu, Ishihama, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518135/
https://ncbi.nlm.nih.gov/pubmed/22964224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.019919
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