Phase I Study and Biomarker Analysis of Lapatinib and Concurrent Radiation for Locally Advanced Breast Cancer

PURPOSE. This phase I study assessed the toxicity and safety of combining daily lapatinib with radiation therapy. Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (HER2) signaling pathways. METHODS. Eligibilit...

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Hlavní autoři: Kimple, Randall J., Horton, Janet K., Livasy, Chad A., Shields, Janiel M., Lawrence, Julia A., Chiu, WingKeung M., Ivanova, Anastasia, Ollila, David W., Carey, Lisa A., Halle, Jan S., Sartor, Carolyn I., Dees, E. Claire
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2012
Témata:
Breast Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528381/
https://ncbi.nlm.nih.gov/pubmed/23006498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0256
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