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Phase I Study and Biomarker Analysis of Lapatinib and Concurrent Radiation for Locally Advanced Breast Cancer
PURPOSE. This phase I study assessed the toxicity and safety of combining daily lapatinib with radiation therapy. Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (HER2) signaling pathways. METHODS. Eligibilit...
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Main Authors: | , , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
AlphaMed Press
2012
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528381/ https://ncbi.nlm.nih.gov/pubmed/23006498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0256 |
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