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Phase I Study and Biomarker Analysis of Lapatinib and Concurrent Radiation for Locally Advanced Breast Cancer

PURPOSE. This phase I study assessed the toxicity and safety of combining daily lapatinib with radiation therapy. Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (HER2) signaling pathways. METHODS. Eligibilit...

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Bibliografiske detaljer
Main Authors: Kimple, Randall J., Horton, Janet K., Livasy, Chad A., Shields, Janiel M., Lawrence, Julia A., Chiu, WingKeung M., Ivanova, Anastasia, Ollila, David W., Carey, Lisa A., Halle, Jan S., Sartor, Carolyn I., Dees, E. Claire
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528381/
https://ncbi.nlm.nih.gov/pubmed/23006498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0256
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