Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significa...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Hargrove, Amanda E., Martinez, Thomas F., Hare, Alissa A., Kurmis, Alexis A., Phillips, John W., Sud, Sudha, Pienta, Kenneth J, Dervan, Peter B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646452/
https://ncbi.nlm.nih.gov/pubmed/26571387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143161
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