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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significa...
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| Veröffentlicht in: | PLoS One |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646452/ https://ncbi.nlm.nih.gov/pubmed/26571387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143161 |
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