The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand

Increased ligand binding to integrin (“activation”) underpins many biological processes, such as leukocyte trafficking, cell migration, host-pathogen interaction, and hemostasis. Integrins exist in several conformations, ranging from compact and bent to extended and open. However, the exact conforma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dai, Aguang, Ye, Feng, Taylor, Dianne W., Hu, Guiqing, Ginsberg, Mark H., Taylor, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646401/
https://ncbi.nlm.nih.gov/pubmed/26391523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682377
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