Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Neurotransmitter:sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and psychostimulants. The prokaryotic NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed by these proteins....

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Billesbølle, Christian B., Krüger, Mie B., Shi, Lei, Quick, Matthias, Li, Zheng, Stolzenberg, Sebastian, Kniazeff, Julie, Gotfryd, Kamil, Mortensen, Jonas S., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Gether, Ulrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646326/
https://ncbi.nlm.nih.gov/pubmed/26363074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677658
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