Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Neurotransmitter:sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and psychostimulants. The prokaryotic NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed by these proteins....

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Billesbølle, Christian B., Krüger, Mie B., Shi, Lei, Quick, Matthias, Li, Zheng, Stolzenberg, Sebastian, Kniazeff, Julie, Gotfryd, Kamil, Mortensen, Jonas S., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Gether, Ulrik
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Membrane Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646326/
https://ncbi.nlm.nih.gov/pubmed/26363074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677658
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