Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Neurotransmitter:sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and psychostimulants. The prokaryotic NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed by these proteins....

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Billesbølle, Christian B., Krüger, Mie B., Shi, Lei, Quick, Matthias, Li, Zheng, Stolzenberg, Sebastian, Kniazeff, Julie, Gotfryd, Kamil, Mortensen, Jonas S., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Gether, Ulrik
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646326/
https://ncbi.nlm.nih.gov/pubmed/26363074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677658
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky