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Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Neurotransmitter:sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and psychostimulants. The prokaryotic NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed by these proteins....

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Billesbølle, Christian B., Krüger, Mie B., Shi, Lei, Quick, Matthias, Li, Zheng, Stolzenberg, Sebastian, Kniazeff, Julie, Gotfryd, Kamil, Mortensen, Jonas S., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Gether, Ulrik
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646326/
https://ncbi.nlm.nih.gov/pubmed/26363074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677658
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