Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Neurotransmitter:sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and psychostimulants. The prokaryotic NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed by these proteins....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Billesbølle, Christian B., Krüger, Mie B., Shi, Lei, Quick, Matthias, Li, Zheng, Stolzenberg, Sebastian, Kniazeff, Julie, Gotfryd, Kamil, Mortensen, Jonas S., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Gether, Ulrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646326/
https://ncbi.nlm.nih.gov/pubmed/26363074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677658
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