Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca(2+) Release

The intracellular Ca(2+) sensor calmodulin (CaM) regulates the cardiac Ca(2+) release channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause arrhythmias such as catecholaminergic polymorphic ventricular tachycardia (CPVT) and long QT syndrome. Here, we investigated the effect of CaM mutatio...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Søndergaard, Mads T., Tian, Xixi, Liu, Yingjie, Wang, Ruiwu, Chazin, Walter J., Chen, S. R. Wayne, Overgaard, Michael T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646266/
https://ncbi.nlm.nih.gov/pubmed/26309258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676627
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