The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor

Mutations in the genes encoding the highly conserved Ca(2+)-sensing protein calmodulin (CaM) cause severe cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia or long QT syndrome and sudden cardiac death. Most of the identified arrhythmogenic mutations reside in the C...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Holt, Christian, Hamborg, Louise, Lau, Kelvin, Brohus, Malene, Sørensen, Anders Bundgaard, Larsen, Kamilla Taunsig, Sommer, Cordula, Van Petegem, Filip, Overgaard, Michael Toft, Wimmer, Reinhard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261784/
https://ncbi.nlm.nih.gov/pubmed/32317284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013430
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