Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is known to bind and modulate more than a 100 targets. Recently, several disease-associated mutations have been identified in the CALM genes that are causative of severe cardiac arrhythmia syndromes. Although several...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wang, Kaiqian, Holt, Christian, Lu, Jocelyn, Brohus, Malene, Larsen, Kamilla Taunsig, Overgaard, Michael Toft, Wimmer, Reinhard, Van Petegem, Filip
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233071/
https://ncbi.nlm.nih.gov/pubmed/30348784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808733115
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky