Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by loss of neurons and formation of pathological extracellular deposits induced by amyloid-β peptide (Aβ). Numerous studies have established Aβ amyloidogenesis as a hallmark of AD pathogenesis, particularly with respect...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Itakura, Masanori, Nakajima, Hidemitsu, Kubo, Takeya, Semi, Yuko, Kume, Satoshi, Higashida, Shusaku, Kaneshige, Akihiro, Kuwamura, Mitsuru, Harada, Naoki, Kita, Akinori, Azuma, Yasu-Taka, Yamaji, Ryoichi, Inui, Takashi, Takeuchi, Tadayoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646260/
https://ncbi.nlm.nih.gov/pubmed/26359500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669291
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