Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme that also mediates cell death by its nuclear translocation under oxidative stress. Meanwhile, we previously presented that oxidative stress induced disulfide-bonded GAPDH aggregation in vitro. Here, we propose that GAPDH...

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Bibliographic Details
Main Authors: Nakajima, Hidemitsu, Amano, Wataru, Kubo, Takeya, Fukuhara, Ayano, Ihara, Hideshi, Azuma, Yasu-Taka, Tajima, Hisao, Inui, Takashi, Sawa, Akira, Takeuchi, Tadayoshi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797201/
https://ncbi.nlm.nih.gov/pubmed/19837666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027698
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